Chronic renal failure–> decreased clearance of phosphate –> hyperphosphatemia –> decreased production of activated vitamin D (1,25 dihydroxy) –> hypocalcemia –> hyperparathyroidism –> hypercalcemia, renal osteodystrophy
hyperphosphatemia –> vascular calcifications –> calciphylaxis (necrotic skin lesions)
Men: decreased testosterone
Women: amenorrhea, infertility, hyperprolactinemia