1st Generation: Cefazolin, Cephalexin
-Gram+
-PEcK: proteus, E. coli, Klebsiella
2nd Generation: Cefoxitin, Cefaclor, Cefuroxime
-Gram+
-HEN PEcKS: Haemophilus, enterobacter, neiseria, Proteus, E. coli, Klebsielia, Serratia
3rd Generation: Ceftriaxone, Ceftaxime, Ceftazidine
-Gram+ but covers also more of Gram-
-Good for serous gram-
-covers HEN PEcKS as well
-Ceftriaxone: gonorrhea, Ceftazidine: pseudomonas
4th Generation: Cefepime, Cefpiramide
-increased activity against Pseudomonas, gram+
-can cross BBB
-has gram- activity like 3rd generation and also covers the HEN PEcKS
5th Generation: Ceftobiprole
-new drug. Good for pseudomonas.
Clindamycin:
-binds 50s ribosomal unit
-good for anaerobes above diaphragm (bacteroides fragilis, clostridium perfringens)
-community acquired infections: use something like Bactrim or Clinda (as apposed to Vancomycin)
Moxifloxacin:
-fluoroquinolone (inhibits DNA gyrase)
-good for gram- rods of Urinary tract and GI tracts (including pseudomonas), Neisseria, and some gram+ organisms.